HIF-1alpha;在肝纤维化中的作用研究进展摘要：肝脏代谢需要充足的氧气供应,一旦缺氧，肝脏将面临十分严重的损伤。
一方面慢性肝损伤伴有缺氧；另一方面，缺氧反过来又加重肝损伤, 抑制肝细胞再生, 促进肝纤维化、肝硬化乃至肝癌的发生；两者互为因果, 互相促进, 是各种慢性肝病发展的重要机制。
作为体内最重要的缺氧信号传递因子,缺氧诱导因子-1alpha;(hypoxia inducible factor-1alpha;, HIF-1alpha;)参与肝脏许多缺氧适应性调节活动，尤其是在肝纤维化中。
目前，随着对肝纤维化与缺氧相互关系的不断认识,针对HIF-1alpha;及其下游靶位的治疗已取得一些进展，该文系统介绍了HIF-1alpha;与肝纤维化的密切关系，深入探究肝纤维化与HIF-1alpha;之间涉及到复杂的信号通路和确切调控机制，为肝纤维化研究和防治提供研究基础和新思路。
关键词：肝纤维化；HIF-1alpha;；慢性肝病；HSCs：血管增生Abstract:Liver metabolism requires ample supply of oxygen, and once hypoxic, the liver will face very severe damage. On the one hand, chronic liver injury is accompanied by hypoxia;On the other hand, hypoxia, in turn, aggravates liver damage, inhibits hepatocyte regeneration, and promotes liver fibrosis, cirrhosis, and even liver cancer. The two are causal and mutually reinforcing, and are important mechanisms for the development of various chronic liver diseases.As the most important hypoxia signaling factor in the body, hypoxia inducible factor-1alpha; (HIF-1alpha;) is involved in many liver hypoxia adaptive regulation activities, especially in liver fibrosis. At present, with the continuous understanding of the relationship between liver fibrosis and hypoxia, some progress has been made in the treatment of HIF-1alpha; and its downstream targets. This paper systematically introduces the close relationship between HIF-1alpha; and liver fibrosis. To explore the complex signaling pathways and precise regulatory mechanisms involved in liver fibrosis and HIF-1alpha;, and provide research basis and new ideas for the study and prevention of liver fibrosis.Key words: liver fibrosis; HIF-1alpha;; chronic liver disease; HSCs: angiogenesis肝纤维化是由酒精滥用、肝炎病毒以及其他各种病因产生的持续性肝损伤或伤口愈合反应而引起的复杂过程，可进一步发展成肝硬化、肝癌。
其主要特征是细胞外基质（extracellular matrix，ECM）蛋白的产生和沉积增加。
在肝脏中影响纤维化产生的最主要细胞是肝星状细胞（hepatic stellate cells，HSC），HSC活化形成肌成纤维细胞样细胞是肝纤维产生的中心环节，并伴随大量ɑ-平滑肌动蛋白（ɑ-smooth actin，ɑ-SMA）、I型胶原alpha;1（type I collagen alpha;1，ColIa1）的产生。
有研究证实纤维化的肝组织中HIF-1alpha;表达升高,并进一步诱导肝纤维化；而HIF-1alpha;基因缺失小鼠肝纤维化程度能够明显改善，但其具体的调控机制还不得而知。
1.HIF-1alpha;的概述与生物学功能肝脏是机体主要的代谢器官, 其正常功能的维持有赖于充分的氧气供应。
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